Difference Between Dry Roll Granulator and High-Speed Wet Granulator

Wet granulator is basically composed of granulating cylinder, stirring paddle, cutter and power system. The technical principle used is mainly to add the drug powder and auxiliary materials to the high-speed stirring granulator, add the binder or wetting agent after mixing evenly and quickly mix and make granules by the action of the high-speed mixer. Among them, the mixing paddle and the cutting blade both adopt variable frequency speed regulation, which is easy to control the particle size. The rotating shaft cavity is inflated and sealed to eliminate dust adhesion. Wet granulator with automatic cleaning function is widely used in powder mixing and adhesive granulation in the pharmaceutical, chemical, food and other industries.

The working principles of the dry granulator

1. The whole process consists of two steps: mixing and drawing.

2. The adhesive enters the material pot from the conical section bucket. After the hopper is closed, the powder material rotates in the container under the agitation of the mixing paddle. At the same time, the material section changes along the direction of the tapered wall to gradually generate a liquid bridge. Under the action of the blades and barrels pressing, rubbing, kneading the materials, the material science gradually turns into loose materials. Then, the department door was opened and the mixed particles pushed out the department bucket under the centrifugal force of the blade.

3. The soft material of the agglomerate structure is not pulled by forced extrusion, but is cut by the granulating force. The soft material is cut into small and uniform particles in a semi-flow state, which realizes the mutual transformation of materials. The purpose of the wet granulator is to fully mix the materials to achieve the ideal mixing state. When the mixing operation is carried out at different stages, the mixing state of the materials is also different.　

The features of wet granulator:

The wet granulation machine can complete the dry material mixing, adding binder, granulation and other processes at one time. The production efficiency is high, and the mixing granulation can be completed within 7-10 minutes. It has good granulation effect, uniform particle size, good fluidity after drying. The mixing time is short and the material generates less friction and heat, so it is also suitable for heat-sensitive materials. Because the entire granulation process is carried out in a closed container, the material dust has little pollution to the air in the clean room and no cross-contamination. There is no dead corner in the mouth, which complies with GMP certification standards. Simultaneously design several safety interlocking devices, so the use of wet granulator is safe and reliable.

Granulating machine manufacturers in the market are various, it’s important to choose a reliable one. When choosing manufacturers, it’s necessary to take sales service, quality guarantee, company certificate into consideration.