How Does the Dry Granulator Better Meet the Needs of Pharmaceutical Granulation?

The powder raw materials of western medicine or traditional Chinese medicine extraction (spray-drying, freeze-drying) generally have the characteristics of different powder particle sizes, uneven density, poor fluidity and easy layering. Therefore, in order to solve the characteristics of these materials, a key processing procedure must be passed-granulation, in order to smoothly perform the processes of tableting, capsule filling, and granule packaging.

It is understood that the dry granulator is a new type of granulation method that is played after the "one-step granulation" of the second-generation granulation method. Granules, especially suitable for materials that are easy to decompose, fail or agglomerate when exposed to moisture and heat.

Among them, the medicinal dry granulator machine is to pour the mixed dry powder material (western medicine or Chinese medicine extract) into a conical hopper. Because the grain itself contains a certain amount of crystal water, the down-spinning feed produces pre-pressure, which compresses and degassed the material. It is first squeezed into slabs, then chopped, and then granulated in a granulation system.

Compared with wet granulation, dry granulation is energy saving, and the processing technology is simple, so the GMP demonstration link is reduced. The floor space is small, so the production and processing costs are lower. In addition, dry granulation does not require any additives and binders. After granulation, the product has uniform particle size, high bulk density, and good fluidity. It is easy to store and transport after granulation, with flying dust and less waste. It’s easy to control the degree of dissolution, porosity and specific surface area, especially for some drugs that are afraid of water or alcohol in solubilization, antibiotics, and highly heat-sensitive drugs that are afraid of heating, the proportion of traditional Chinese medicine extracts failing to meet the requirements, and the addition of binders or auxiliary drugs must be completed by dry granulation.

In addition, the medicinal dry granulator machine is simple and convenient to disassemble and clean. The internal and external sealing structure of the hood is reasonably designed. The electrical box and transmission are waterproof. There is no need to worry about the pollution and damage to the electrical appliances and the equipment during the clearance process. At present, the use of dry granulation mechanism granulation has become a mainstream trend.

In the process of pharmaceutical granulation production, with the wide application of dry granulation and the continuous increase of pharmaceutical granulation requirements, the technical requirements of pharmaceutical enterprises for dry granulation machines will also become higher and higher. Among them, cleanliness and flexible functions will become common goals pursued by the industry.

In the future, dry granulators will meet the requirements of cleanliness and flexible functions. First, a completely closed dry granulation system can reduce dust pollution during production, thereby reducing the risk of pollution and pollution. Second, the equipment adopts a modular design, and the entire granulation device can be disassembled with only a few tools. It is easy to clean all module units, and the screws and rollers can be easily replaced to adapt to different pelletizing tasks.

At present, although domestic granulation equipment can basically meet the needs of the pharmaceutical industry, related companies lack investment in technology research and development and innovation.